Lake City, South Carolina, is situated in the northeastern part of the state, within Florence County. It lies approximately 75 miles east of Columbia, the state capital, and roughly 90 miles west of Myrtle Beach, a popular coastal destination. Its geographic coordinates place it near the intersection of major highways, facilitating accessibility.
The location of this municipality contributes significantly to its regional role as an agricultural and commercial hub. Historically, its proximity to fertile farmland has fostered its development as a center for tobacco and other agricultural products. This, in turn, has driven economic activity and established it as a point of connection for surrounding rural communities. Its position also makes it accessible for residents of larger cities seeking a more tranquil lifestyle.